This is an invasive lobular carcinoma, solid variant. More than 90% of tumour cells are ER positive and 40% of tumour cells are PR positive.
The tumour has a demarcated border and predominently formed by large solid nests of cells devoid of stroma. But in some areas tumour cells are arranged in typical Indian file pattern. These cells are discohasive, small and uniform with scan cytoplasm. No in situ lesion is identified in this case.
Two features to help to differentiate from lymphoma: 1. Typical Indian file infiltrating pattern. 2. Uniform cells with smooth nuclear contour, indistinct nuclear membrane and fine chromatin.
I admit that slides are much more clearer than photos.
This is an invasive lobular carcinoma, solid variant. More than 90% of tumour cells are ER positive and 40% of tumour cells are PR positive.
The tumour has a demarcated border and predominently formed by large solid nests of cells devoid of stroma. But in some areas tumour cells are arranged in typical Indian file pattern. These cells are discohasive, small and uniform with scan cytoplasm. No in situ lesion is identified in this case.
Two features to help to differentiate from lymphoma: 1. Typical Indian file infiltrating pattern. 2. Uniform cells with smooth nuclear contour, indistinct nuclear membrane and fine chromatin.
I admit that slides are much more clearer than photos.