本帖最后由 于 2008-04-12 14:55:00 编辑
Follicular dendritic cell sarcoma vs. Interdigitating dendritic cell sarcoma
|
Follicular dendritic cell sarcoma |
Interdigitating dendritic cell sarcoma |
Location of
Normal Counterpart |
Germinal Center |
T cell areas (paracortex and interfollicular areas of
lymph node, splenic periarteriolar lymphoid sheaths) |
Origin |
Mesenchymal |
the monocyte-macrophage lineage |
Electron microscopy |
Numerous long, slender cytoplasmic processes connected by desmosomes |
Complex interdigitating cellular junctions |
CD21 |
+ |
- |
CD35 |
+ |
- |
S100 |
- |
+ |
CD23 |
+ |
- |
Clusterin |
+ |
- |
CD1a |
- |
- |
HMB-45 |
- |
- |
CD3 |
- |
- |
CD20 |
- |
- |
CD45 |
- |
+/- |
CD68 |
- |
- |
Lysozyme |
- |
- |
-
CD21: CR2-complement component (3d) receptor 2, and EBV receptor;
-
CD23: IgE Fc receptor, FcεRII;
-
CD35: erythrocyte complement receptor 1 (CR1, also known as C3b/C4b receptor and immune adherence receptor)
-
Clusterin: designated complement lysis inhibitor (CLI), apolipoprotein J (APOJ), sulfated glycoprotein 2 (SGP2), SP-40 and testosterone-repressed prostate message 2 (TRPM2). A marker of ALCL. |
Reference |
-
Am J Clin Pathol. 2007 Nov;128(5):776-82.
-
Am. J. Hematol. 82:924?28, 2007
-
USCAP, Denver, 2008. Abstract 1169 and 1175 |
|
Summarized by Zenggang Pan, MD, PhD |
Follicular dendritic cell sarcoma vs. Interdigitating dendritic cell sarcoma
|
Follicular dendritic cell sarcoma |
Interdigitating dendritic cell sarcoma |
Location of
Normal Counterpart |
Germinal Center |
T cell areas (paracortex and interfollicular areas of
lymph node, splenic periarteriolar lymphoid sheaths) |
Origin |
Mesenchymal |
the monocyte-macrophage lineage |
Electron microscopy |
Numerous long, slender cytoplasmic processes connected by desmosomes |
Complex interdigitating cellular junctions |
CD21 |
+ |
- |
CD35 |
+ |
- |
S100 |
- |
+ |
CD23 |
+ |
- |
Clusterin |
+ |
- |
CD1a |
- |
- |
HMB-45 |
- |
- |
CD3 |
- |
- |
CD20 |
- |
- |
CD45 |
- |
+/- |
CD68 |
- |
- |
Lysozyme |
- |
- |
-
CD21: CR2-complement component (3d) receptor 2, and EBV receptor;
-
CD23: IgE Fc receptor, FcεRII;
-
CD35: erythrocyte complement receptor 1 (CR1, also known as C3b/C4b receptor and immune adherence receptor)
-
Clusterin: designated complement lysis inhibitor (CLI), apolipoprotein J (APOJ), sulfated glycoprotein 2 (SGP2), SP-40 and testosterone-repressed prostate message 2 (TRPM2). A marker of ALCL. |
Reference |
-
Am J Clin Pathol. 2007 Nov;128(5):776-82.
-
Am. J. Hematol. 82:924?28, 2007
-
USCAP, Denver, 2008. Abstract 1169 and 1175 |
|
Summarized by Zenggang Pan, MD, PhD |