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肉眼检查: |
In fact there is no special treatment for basal-lik ca currently.
In our hospital we make diagnosis based on the following:
1. All invasive mammary ca: ER/PR/Her2(plus KI67)
2. All triple negative cases, we will do ck5 (ck5/6)/EGFR/ck14/ck17.
3. if above some of the markers are positive, we will call invasive ductal ca with basal-like phenotype.
4. For these classic metaplastic ca we will call metaplastic carcinoma and will not do basal-like markers for them. We will not call them as basal-like ca even though most of them will be positive for basal-like markers.
5. In the USA pathologists in many hospitals will not stain the basal-like markers for triple negative tumors. In other words it is required by CAP now.
Finally, we should know that basal-like carcinoma is a heterogenous group of tumors.
事实上目前对基底细胞样癌没有特别的处理方案。
在我们医院,基于以下情况做诊断:
1.所有的浸润性癌:ER/PR/Her2(加KI67).
2.所有三阴性病例,我们将标记ck5 (ck5/6)/EGFR/ck14/ck17。
3.如果上面的指标部分阳性,我们称之为具有基底样表型的浸润性导管癌。
4.对这些典型的化生性癌我们称之为化生性癌并且不再对其做基底样标记。我们不诊断为基底细胞样癌即使它们中大部分基底样标记为阳性。
5.在美国许多医院的病理医生对三阴性的病例不做基底细胞样的标记。换句话说,现在它不是CAP(
)要求必做的。
最终我们应当知道:基底细胞样癌是肿瘤的一种变异形态。
(quyibl译)
以下是引用abin在2009-9-4 23:23:00的发言:
WHO 2003 关于髓样癌有5个诊断特征,本例都符合。 典型的MC具备五大形态特征: |