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脊髓肿物

redsnow007 离线

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楼主 发表于 2009-08-28 16:42|举报|关注(0)
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姓    名: ××× 性别:  男 年龄: 27 
标本名称:  C1-5脊髓外椎管内占位
简要病史:  右上肢麻木4年,右下肢麻木2月余
肉眼检查:  
  • 脊髓肿物图1
    图1
  • 脊髓肿物图2
    图2
  • 脊髓肿物图3
    图3
  • 脊髓肿物图4
    图4
  • 脊髓肿物图5
    图5
  • 脊髓肿物图6
    图6
  • 脊髓肿物图7
    图7
  • 脊髓肿物图8
    图8
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stevenshen 离线

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1 楼    发表于2009-08-31 04:19:00举报|引用
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I am not an expert of neuropathologist...I think this case will need some expertise in neuropathology.

The most striking features are a cellular neoplasm with thick and hyalinized vessels.

I would guess: schwannoma, ependymoma, or meningioma...

 

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xianren 离线

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2 楼    发表于2009-08-31 10:06:00举报|引用
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 有钙化,考虑为脊膜瘤
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redsnow007 离线

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3 楼    发表于2009-08-31 10:46:00举报|引用
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头颅MRI提示:肿瘤在T1相上呈等信号,稍混杂,从C1-C5,边界欠清。T2相上肿瘤呈腊肠样,边界不清,略高信号,呈侵蚀性生长。根据肿瘤周边的脊髓可见肿瘤是从脊髓内长出。强化片示无明显强化,边界不清,明显的侵袭性生长。
  • 图1
  • 图2
  • 图3
  • 图4
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redsnow007 离线

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4 楼    发表于2009-08-31 10:50:00举报|引用
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 手术所见:C1-C5段肿胀,正常脊髓受推挤偏于左侧,肿瘤位于髓内,偏据右侧。肿瘤淡红色,质硬,占据椎管大部分,有较完整包膜,与局部脊髓紧密粘连。

大体:灰红,长条形,大小2*1.5*5cm。

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海上明月 离线

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5 楼    发表于2009-09-01 12:48:00举报|引用
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 谢谢提供MRI影像,还是考虑脊膜来源。提供的HE图片中偶见沙粒体样结构,呈脊(脑)膜上皮型,偶见乳头状生长。局灶疑有核分裂。有的视野下可见细胞呈横纹肌样。当然,冰冻切片染色的细胞比石蜡切片的细胞要“胖”些。很难说有没有异型性。如果石蜡切片看到上述情况,并可见核分裂和/或小灶坏死,而且免疫组化标记支持脊膜来源,细胞增殖标记显示较活跃,结合包膜有无浸润以及临床表现,那就应该诊断为非典型性脊膜瘤,WHOII级。如果石蜡和IHC不支持脊膜来源,那我就学习了一回。谢谢!
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fyshan 离线

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6 楼    发表于2009-09-01 02:27:00举报|引用
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I think ependymoma, your description of "呈腊肠样" is classic. please do immunostains of GFAP and EMA to confirm. If you are sure the tumor is outside the spinal cord parenchyma, meningioma is another option.

Location is a key.

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ZQH19811029 离线

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7 楼    发表于2009-12-16 19:17:00举报|引用
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考虑为脊膜瘤
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hp200018 离线

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8 楼    发表于2009-09-02 21:35:00举报|引用
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 学习
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9 楼    发表于2009-09-02 22:21:00举报|引用
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 请问一楼同仁,IHC及其最后诊断的结果有吗?我想打听一下。
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redsnow007 离线

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10 楼    发表于2009-09-03 17:01:00举报|引用
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 免疫组化:CK(-),EMA(-),VIM(+),GFAP(+),S-100(+),NF(-),CGA(-),SYN(-)。
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11 楼    发表于2009-09-05 02:18:00举报|引用
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 请见下列文献:

1: Clin Neurol Neurosurg. 2009 Sep;111(7):619-23. Epub 2009 May 30.

Click here to read
Diffuse craniospinal metastases of intraventricular rhabdoid papillary meningioma with glial fibrillary acidic protein expression: a case report.

Eom KS, Kim DW, Kim TY.

Department of Neurosurgery, Wonkwang University School of Medicine, Iksan 570-749, Republic of Korea.

Rhabdoid papillary meningioma is a recently described clinically aggressive variant of meningiomas with a high recurrence rate. Additionally, only one case of intraventricular rhabdoid meningioma has been reported so far. We present a case of a 50-year-old man who developed an intracranial tumor of the left lateral ventricle at the trigone, for which he underwent total tumor resection followed by gamma knife radiosurgery for recurrence of the tumor. The histological diagnosis was rhabdoid papillary meningioma. Five years after surgery, diffuse craniospinal leptomeningeal metastases developed and subtotal removal of the spinal tumor was performed. The spinal tumor was considered to have metastasized via cerebrospinal fluid (CSF) in view of its histological features that were identical to those of the primary tumor. Immunohistochemistry revealed the unusual cytoplasmic expression of glial fibrillary acidic protein (GFAP) of tumor cells. To our knowledge, this is the first reported case of diffuse craniospinal metastases of intraventricular rhabdoid papillary meningioma with GFAP expression and the second reported case of the rhabdoid subtype amongst intraventricular meningiomas.

Publication Types:
PMID: 19482417 [PubMed - in process]

Click here to read
Meningioma with extensive noncalcifying collagenous whorls and glial fibrillary acidic protein expression: new variant of meningioma diagnosed by smear preparation.

Pope LZ, Tatsui CE, Moro MS, Neto AC, Bleggi-Torres LF.

Department of Pathology (Neuropathology), Universidade Federal do Paraná, Curitiba, Brasil.

The purpose of this report is to describe the unique cytological findings of a new recently characterized type of meningioma that has extensive noncalcifying collagenous whorls and glial fibrillary acid protein (GFAP) expression. This new entity, described by Haberler and colleagues, was named whorling sclerosing variant of meningioma. The patient was a 34-yr-old white man with a large tumor in the brainstem. Intraoperative smear preparations showed a tumor with a large number of solid hyaline masses in a loose background and in focal areas tumor cells formed cohesive nests with a somewhat whorling appearance. The histological sections showed a neoplasia composed of innumerable eosinophilic, collagenous, noncalcified round deposits, cuffed by scattered meningothelial tumor cells. The neoplastic cells showed diffuse cytoplasmic reactivity for EMA and vimentin, as well as positivity to GFAP. This is the first cytological description of this new entity in the literature. Copyright 2003 Wiley-Liss, Inc.

Publication Types:
PMID: 12722124 [PubMed - indexed for MEDLINE]


An unusual meningioma variant with glial fibrillary acidic protein expression.

Su M, Ono K, Tanaka R, Takahashi H.

Department of Pathology, Niigata University, Japan.

We studied a recurrent meningioma located in the right frontal lobe. The tumor showed high cellularity and the cells had plump, hyalinous cytoplasm. Immunohistochemically, almost all the tumor cells were positive for epithelial membrane antigen and vimentin, and unexpectedly, glial fibrillary acidic protein (GFAP). Ultrastructural investigation revealed abundant 8- to 10-nm filaments in the cytoplasm. Conspicuous interdigitations with numerous desmosomes were present. Frequently, intracellular and intercellular lumina lined by microvilli were also found. We considered the present case to be an unusual variant of meningioma with GFAP expression. A few cases of meningioma with triple expression of GFAP, vimentin and cytokeratin have been reported previously. However, the present case showed obvious pathological differences from these, and had no immunoreactivity for cytokeratin.

Publication Types:
PMID: 9386784 [PubMed - indexed for MEDLINE]


Suprasellar meningioma with expression of glial fibrillary acidic protein: a peculiar variant.

Wanschitz J, Schmidbauer M, Maier H, Rössler K, Vorkapic P, Budka H.

Institute of Neurology, University of Vienna, Austria.

A 24-year-old female presented with a 3-year history of a suprasellar and intraventricular solid midline process measuring about 3 x 4 cm. At surgery, this tumour was sharply delineated and of stone-like firmness and was removed completely. Histology suggested meningioma, featuring nests and cords of epithelium-like cells with prominent cytoplasm amidst abundant fibrous stroma with prominent lymphoplasmocellular infiltration. Immunocytochemically, the tumour cells expressed vimentin, S-100 protein, epithelial membrane antigen, cytokeratins, and most surprisingly, glial fibrillary acidic protein (GFAP). Ultrastructural investigation revealed abundant intermediate filaments and occasionally dense secretory granules in tumour cells with short, finger-like cytoplasmic processes joined by very rare small, but well-developed desmosomes. This tumour most likely represents a peculiar variant of meningioma with prominent production of GFAP, as previously described [Budka H (1986) Acta Neuropathol (Berl) 72: 43-54].

Publication Types:
PMID: 8560989 [PubMed - indexed for MEDLINE]


Non-glial specificities of immunocytochemistry for the glial fibrillary acidic protein (GFAP). Triple expression of GFAP, vimentin and cytokeratins in papillary meningioma and metastasizing renal carcinoma.

Budka H.

In an extensive immunocytochemistry study for glial fibrillary acidic protein (GFAP) of human neuropathological biopsy or autopsy tissue specimens examined for diagnostic or research purposes, rare non-glial specificities of the GFAP immunostain were observed: Schwann cells of some small nerves in salivary gland, renal capsule, and in epidural fat adjacent to a metastatic carcinoma, Schwann and satellite cells in a spinal ganglion invaded by tumor, chondrocytes of epiglottic cartilage, few cells of a malignant pleomorphic adenoma of salivary gland, most cells of a recurrent papillary meningioma with areas similar to the hemangiopericytic variant, and many cells of a renal carcinoma metastatic to brain; the primary renal tumor had been operated 4 years earlier and focally contained some GFAP-positive cells. To ascertain the specificity of such unexpected immunoreactivities for GFAP and to exclude possible crossreactivities with other intermediate filament (IF) proteins, a panel of different antibodies was used for immunocytochemistry with the peroxidase-antiperoxidase (polyclonal antisera) or labeled biotin-avidin (monoclonal antibodies) techniques: two monoclonal and four polyclonal anti-GFAP, three monoclonal and one polyclonal anti-cytokeratins (CK), and two monoclonal anti-vimentin (VIM) antibodies. Triple expression of GFAP, VIM and CK was found in the papillary meningioma (in patterns suggesting frequent co-localization), in the metastatic carcinoma (in patterns suggesting little co-localization), and in the pleomorphic adenoma (only few GFAP-positive cells). Co-expression of GFAP and VIM was seen in epiglottic chondrocytes and reactive astroglia; another metastatic carcinoma was labeled only for CKs. In the light of previous reports on non-glial specificities of the GFAP immunostain, and of the consistency of our immunostaining results obtained by all monospecific anti-GFAP antibodies as well as the lack of immunocytochemically evident crossreactivity with other IF proteins, authentic GFAP production by some rare non-glial tissues and tumors is suggested.

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王军臣

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12 楼    发表于2009-09-05 16:18:00举报|引用
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 所以,我还是坚持脊膜来源的肿瘤。

若是室管膜瘤的话,恶性肿瘤长了4年以上,那还了得。

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13 楼    发表于2009-09-11 19:46:00举报|引用
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 有两周了.

请问楼主,最终报告啥.

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lanyueliang 离线

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14 楼    发表于2009-08-28 17:02:00举报|引用
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 冰冻切片吧
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redsnow007 离线

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15 楼    发表于2009-08-28 20:03:00举报|引用
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是冰冻切片
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16 楼    发表于2009-08-29 14:09:00举报|引用
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 请提供CT片和大体标本的照片(或描述).
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海上明月 离线

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17 楼    发表于2009-08-29 14:29:00举报|引用
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 首先考虑是脊膜来源的肿瘤—脊膜瘤(上皮型),然后才考虑神经鞘膜瘤可能。在术前术中需要复习影像学资料,结合影像学、巨检和组织病理所见来诊断。最后,需石蜡切片作IHC鉴别诊断。
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丁学海 离线

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18 楼    发表于2009-08-29 14:44:00举报|引用
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 咋像浆细胞?
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晨曦2007 离线

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19 楼    发表于2009-08-30 11:40:00举报|引用
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 期待石蜡切片
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redsnow007 离线

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20 楼    发表于2009-08-30 15:59:00举报|引用
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 这是上周五我们科遇到的冰冻,明天给大家提供影像和大体的资料,石蜡切片还要等等
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