This is my first time to see the "ring" shaped casts. Some of the casts have cellular reaction. But these reactive cells are probably macrophages, not neutrophils or multinucleated giant cells. At this moment, I am think about cast nephropathy (light chain associated). Or if patient has recent history of rhabdomyolysis, immunohistochemical stains for skeletal marker may be helpful.
This is my first time to see the "ring" shaped casts. Some of the casts have cellular reaction. But these reactive cells are probably macrophages, not neutrophils or multinucleated giant cells. At this moment, I am think about cast nephropathy (light chain associated). Or if patient has recent history of rhabdomyolysis, immunohistochemical stains for skeletal marker may be helpful.
I agree with Dr. Geng's diagnosis. Hemoglobinuric acute tubular necrosis is probably the most reasonable diagnosis though the nature of the casts has not be identified immunohistochemically.Hemoglobin and heme pigments are known nephrotoxins which may lead to ATN.
I agree with Dr. Geng's diagnosis. Hemoglobinuric acute tubular necrosis is probably the most reasonable diagnosis though the nature of the casts has not be identified immunohistochemically.Hemoglobin and heme pigments are known nephrotoxins which may lead to ATN.