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- 外阴Paget病和EMPD简要总结介绍(cqz-2)
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Thank Dr. Zhang's good differential dx. When we see these kinds of lesions we must consider the differential dx. Three ddx including Paget's, Bowen, and melanoma should be in our mind immediately. The treatment and prognosis of these diseases can be huge different. We always do some stains for these lesions even though we can favor some dx based on H@E. You can be right in most of the time, but you will be wrong some time during your life long practice.
This is a vulvar Paget's/primary Paget's or called Extramammary Paget’s Disease
One of our first year residents made some summary about Paget's and showed in our morning study conference. I pasted the summary in the following.
As pathologists we should know lesions in more detailed. It is not enough to make dx only.
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本帖最后由 于 2009-08-22 07:43:00 编辑
Vulvar EMPD
n 65% cases of EMPD
n Most cases are primary
n 4-17% associated with underlying adnexal neoplasm
n 11-20% associated with distant carcinoma
n Endometrial, endocervical, vaginal, bladder, colon, rectum, ovary, liver, gallbladder, skin
Differential Diagnosis
n Melanoma
n Bowen's disease
n Seborrheic or contact dermatitis
n Superficial fungal infections
n Basal cell carcinoma
n Flexural psoriasis
n Lichen sclerosus
