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- NP (1) - WHO grade I pilocytic astrocytoma
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The photos below are taken from frozen section of a resected cerebellar tumor (focally cystic with enhancing solid nodule) from a 2 year old girl.
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本帖最后由 于 2006-10-19 08:50:00 编辑
聞道有先後,術業有專攻
×参考诊断
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本帖最后由 于 2006-10-09 22:13:00 编辑
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Figures 1~4 were taken from frozen sections, and were uploaded first. The remaining photos were taken from permanent sections, and were planned to be posted later. I uploaded and placed them in the same folder as the first 4 photos, and unknowingly posted all of them together. Now I know and will not make the same mistake again. Figures 1~12 show very classic features of a WHO grade I pilocytic astrocytoma. Figures 11~12 are taken from the cystic wall of the tumor. As you can see, neither eosinophilic granular bosies nor Rosenthal fibers are necessary for the diagnosis of pilocytic astrocytoma.
Figures 13~14 show Bergman gliosis of adjacent degenerated cerebellar cortex that may be confused with gliomatous involvement. This can be difficult to tell at intraoperative consultation. One helpful hint is its laminated appearance conforming to the pre-existing interface of molecular and Purkinje cell layers. If one or two residual Purkinje cells remain, the task will be a lot easier.
聞道有先後,術業有專攻
尝试翻译一下，不足之处请指正：
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一楼：
下图是一2岁女孩的小脑肿瘤切除标本的冰冻切片（局部呈囊状伴结节）
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毛细胞性星形胶质细胞瘤
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图1-4来自冰冻切片，是最开始上传的。剩下的图片来自常规切片，本打算稍后贴出的。我把它们和前4张图放在一个文件夹中上传，不自觉的就一起都贴出来了。现在我知道了以后不会再犯同样的错误了。图1-12显示了WHO I级毛细胞性星形细胞瘤的经典特征。图11-12显示的是肿瘤的囊壁。正如你所看到的，嗜酸性颗粒小体或Rosenthal 纤维并非诊断毛细胞性星形细胞瘤所必需的。
图13-14邻近变性的小脑皮质的Bergman神经胶质增生或许会和神经胶质瘤累及相混淆。在术中诊断时很难区分。一个有帮助的提示在于它的层状外观和先前存在的分子层和蒲肯野细胞层界面相一致。如果有1、2个残存的蒲肯野细胞的话，这个任务就会变得很轻松了。
