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Inflammation or invasive lobular carcinoma

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楼主 发表于 2009-08-01 07:20|举报|关注(0)
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姓    名: ××× 性别: Female 年龄:  54
标本名称: breast excision
简要病史: Prior core biopsy diagnosis of invasive lobular carcinoma, now with excision
肉眼检查: A dense tissue at margin  

What's your frozen section diagnosis and why?

  • Inflammation or invasive lobular carcinoma图1
    图1
  • Inflammation or invasive lobular carcinoma图2
    图2
  • Inflammation or invasive lobular carcinoma图3
    图3
  • Inflammation or invasive lobular carcinoma图4
    图4
  • Inflammation or invasive lobular carcinoma图5
    图5
  • Inflammation or invasive lobular carcinoma图6
    图6
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Invasive lobular carcinoma

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1 楼    发表于2009-08-31 03:55:00举报|引用
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I cannot find the high power pictures.

The answer is: invasive lobular carcinoma.

From the reponses, there were almost equal numbers of "inflammatory" and "neoplastic".

I hope this case demonstrated a couple of points and hope you enjoy it.

1. It is very difficult to differentiate inflammatory cells and invasive lobular (frozen)

2. One might be able to find very subtle clues for the diagnosis by careful examination of all pictures 

3. There are single rows of tumor cells (Fig.2 and 3)

4. Very unusual for inflammatory cells to infiltrate "dense" stroma in an organized fashion (Fig. 6) 

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2 楼    发表于2009-08-21 11:08:00举报|引用
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Thanks for all the response and discussion.

I hope that this case will highlight the difficulties of breast tissue frozen.

To answer Abin's question...yes, the frozen is for diagnosis and margin evaluation.

I think the most helpful photo are figure 2, 3, and 6.

I might have a few high magnification photos.

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