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制品公司涉及的臨床宫颈癌普查试验在印度-有夸大HPV检测和贬低细胞学检测的倾向,误导读者

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The paper HPV screening for cervical cancer in rural India published in N Engl J Med.(one of the most important journal of medicine in the world) 2009 Apr 2;360(14):1385-94.

The conclusion of the paper: In a low resource setting, a single round of HPV testing was associated with a significant reduction in the numbers of advanced cancers or deaths from cervical cancer.Furthermore, the study abstract asserted, "No significant reductions in the numbers of associated deaths were observed in the cytology testing group or in the VIA group, as compared with the control group".

 

In other words, this clinical trial in India demostrate HPV testing can reduce the rate of cervical cancer and its related death, but Pap cytology and VIA have no reduction of cervical cancer related death, same as no any test group (control).

The authors manupulated the statistical numbers and made the results they hope to have.

Why? Industry-company involved the clinical trials. Interests are what people are looking for.

 

I pasted the original abstract here and also Dr. Austin and I wrote the editorial commentary.

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