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- B2160浸润性导管癌伴大汗腺特征,morphology like histiocytoid or granular cell tumor (cqz-24) 7-16-2009
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本帖最后由 于 2009-07-21 18:26:00 编辑
http://www.ipathology.cn/forum/forum_display.asp?keyno=147152
Is there any other differential dx
abin译：
请参考http://www.ipathology.cn/forum/forum_display.asp?keyno=147152（组织细胞样型乳腺癌looks like 颗粒细胞瘤 (cqz 17)）
是否有其他鉴别诊断？
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本帖最后由 于 2009-07-21 18:31:00 编辑
tumour cells are diffusely infiltrating in the stroma. There is no obvious glandular structure. However, the cells appear cohesive and frequently clustered together. They have abundant pale blueish (more mucinous-like) cytoplasm instead of eosinophilic granular cytoplasm as in histiocytoid lobular carcinoma. Tumour cells also have ill-defined borders as opposed to lobular carcinoma. So if this is an example of lobular carcinoma, i think it is very atypical. This is a case with an usual appearance. I would consider following differentials: 1. Primary and malligant--- invasive ductal ca. 2. ? Metastatic tumur. 3. ? silicon reaction
abin译：
肿瘤细胞弥漫浸润间质，没有明显腺样结构。然而，细胞有粘附性，多见成簇聚集。胞浆丰富，蓝汪汪（很像粘液样），而不是组织细胞样型小叶癌中的嗜酸性颗粒性胞浆。肿瘤细胞边界不清楚，这与小叶癌也不同。因此，这例如果是小叶癌，我认为是一种非常不典型的病例。本例有少见形态表现，我考虑的鉴别诊断：1、原发性、恶性--浸润性导管癌。2、转移性肿瘤？3、硅胶反应？
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本帖最后由 于 2009-07-30 14:04:00 编辑
| 以下是引用漫游人在2009-7-21 15:30:00的发言：
tumour cells are diffusely infiltrating in the stroma. There is no obvious glandular structure. However, the cells appear cohesive and frequently clustered together. They have abundant pale blueish (more mucinous-like) cytoplasm instead of eosinophilic granular cytoplasm as in histiocytoid lobular carcinoma. Tumour cells also have ill-defined borders as opposed to lobular carcinoma. So if this is an example of lobular carcinoma, i think it is very atypical. This is a case with an usual appearance. I would consider following differentials: 1. Primary and malligant--- invasive ductal ca. 2. ? Metastatic tumur. 3. ? silicon reaction abin译： 肿瘤细胞弥漫浸润间质，没有明显腺样结构。然而，细胞有粘附性，多见成簇聚集。胞浆丰富，蓝汪汪（很像粘液样），而不是组织细胞样型小叶癌中的嗜酸性颗粒性胞浆。肿瘤细胞边界不清楚，这与小叶癌也不同。因此，这例如果是小叶癌，我认为是一种非常不典型的病例。本例有少见形态表现，我考虑的鉴别诊断：1、原发性、恶性--浸润性导管癌。2、转移性肿瘤？3、硅胶反应？ |
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本帖最后由 于 2009-08-03 20:47:00 编辑
Just complete today's cases. Feel released now. for this weekend night. I will tell you some IHC before I go to home.
Thank all of you for your very reasonable discusion.
AE1/AE3 strongly and diffusely positive.
F1 S-100
F2 CD68.
abin译：
刚完成今天的病例，觉得轻松了。在这周末之夜，在回家前，先告诉大家一些免疫组化结果。
谢谢所有参与讨论的人，你们的观点非常合理。
AE1/AE3 弥漫强阳性
图1 S-100
图2 CD68
名称：图1
描述：图1
名称：图2
描述：图2
