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- 请大家谈谈对肿瘤干细胞的认识
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最近在看肿瘤干细胞方面的文章，也在丁香园里面看到这方面的讨论还是比较激烈的，想在此处也开个话题，大家共同关注一下。欢迎各位多多发表自己的看法。
肿瘤干细胞（Cancer stem cell/Tumor stem cell）是具有自我更新能力，通过对称和不对称两种分裂形式产生新的肿瘤干细胞和具有无限增殖能力并分化成不同表型细胞群的细胞。肿瘤干细胞是决定肿瘤发生和转移的肿瘤细胞群体，在恶性肿瘤的发生和发展中发挥重要作用，是肿瘤治疗的靶细胞。1994年Lapidot 等首次通过特异细胞表面标志分离出了人急性粒细胞白血病干细胞，其表型为CD34+/CD38-，该发现为肿瘤干细胞的存在提供了实验依据。
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发一个新看到的文章，对这方面比较感兴趣，欢迎大家讨论哦不过只有摘要哦
A Perivascular Niche for Brain Tumor Stem Cells
Summary
Cancers are believed to arise from cancer stem cells (CSCs), but it is not known if these cells remain dependent upon the niche microenvironments that regulate normal stem cells. We show that endothelial cells interact closely with self-renewing brain tumor cells and secrete factors that maintain these cells in a stem cell-like state. Increasing the number of endothelial cells or blood vessels in orthotopic brain tumor xenografts expanded the fraction of self-renewing cells and accelerated the initiation and growth of tumors. Conversely, depletion of blood vessels from xenografts ablated self-renewing cells from tumors and arrested tumor growth. We propose that brain CSCs are maintained within vascular niches that are important targets for therapeutic approaches. CANCERCELL Volume 11, Issue 1, January 2007, Pages 69-82
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