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pathologyliu 离线
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本帖最后由 于 2009-06-14 11:02:00 编辑
LAH (lymphocytic adenohypophysitis) is more common in women (F:M ratio, 6:1), who tend to present at a younger age (35±13 yr) than males (45±14yr). In a significant percentage of women ,LAH manifests during pregnancy or postpartum.
As for the PRL level might be explained by "Stalk-compression effect"--- The release of prolactin is negatively regulated by the hypothalamus through the portal system (involve dopamine). Any compression of the pituitary stalk will lead to the loss of suppression and results in increased release of prolactin. But the prolactin level should not exceed 150 ng/mL. Prolactin secreting adenomas usually have higher serum prolactin level.
The inflammatory process may also directly destroy the lactotrophs,inducing release of PRL into the general circulation (similar to the release of preformed thyroid hormones seen in destructive thyroiditides such as type 2 amiodarone-induced thyrotoxicosis and subacute thyroiditis).
LAH淋巴细胞性垂体腺瘤常见于女性，男：女＝1:6,女性患者年龄年轻于男性（分别35＋－13岁，45+ -14岁）。女性更常见于妊娠和产后。
至于PRL水平被解释为垂体柄压迫效应，催乳素的释放通过门脉系统（包括多巴安等）受下丘脑负调节。垂体柄受压，导致失去抑制，催乳素释放增加。但催乳素不会超过150ng/ml。分泌催乳素的腺瘤通常血清催乳素更高。炎症可能直接破坏泌乳细胞，包括催乳素释放于体循环（与破坏性的甲状腺炎如2型乙胺碘呋酮诱发的毒性甲状腺肿及亚急性甲状腺炎中的甲状腺激素的释放类似）。
liguoxia71试译
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wangxuanju 离线
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wangxuanju 离线
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引用 4 楼 pathologyliu 在 2009-06-14 12:36:00 的发言:
LAH (lymphocytic adenohypophysitis) is more common in women (F:M ratio, 6:1), who tend to present at a younger age (35±13 yr) than males (45±14yr). In a significant percentage of women ,LAH manifests during pregnancy or postpartum.
As for the PRL level might be explained by "Stalk-compression effect"--- The release of prolactin is negatively regulated by the hypothalamus through the portal system (involve dopamine). Any compression of the pituitary stalk will lead to the loss of suppression and results in increased release of prolactin. But the prolactin level should not exceed 150 ng/mL. Prolactin secreting adenomas usually have higher serum prolactin level.
The inflammatory process may also directly destroy the lactotrophs,inducing release of PRL into the general circulation (similar to the release of preformed thyroid hormones seen in destructive thyroiditides such as type 2 amiodarone-induced thyrotoxicosis and subacute thyroiditis).
LAH淋巴细胞性垂体腺瘤常见于女性，男：女＝1:6,女性患者年龄年轻于男性（分别35＋－13岁，45+ -14岁）。女性更常见于妊娠和产后。
至于PRL水平被解释为垂体柄压迫效应，催乳素的释放通过门脉系统（包括多巴安等）受下丘脑负调节。垂体柄受压，导致失去抑制，催乳素释放增加。但催乳素不会超过150ng/ml。分泌催乳素的腺瘤通常血清催乳素更高。炎症可能直接破坏泌乳细胞，包括催乳素释放于体循环（与破坏性的甲状腺炎如2型乙胺碘呋酮诱发的毒性甲状腺肿及亚急性甲状腺炎中的甲状腺激素的释放类似）。
liguoxia71试译
译的不好，炎和瘤差别大了，
- jx16
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