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Transplant kidney biopsy

quhong 离线

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楼主 发表于 2009-04-20 23:48|举报|关注(0)
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姓    名: ××× 性别:  Woman 年龄:  38
标本名称:  Allograft kidney, needle biopsy.
简要病史: Kidney transplant 3 months ago, with elevated creatinine. Prior biopsy showed acute tubular necrosis.
肉眼检查:  Unremarkable.
The last photo shows immunohistochemical stain for C4d.
Transplant kidney biopsy图1
名称:图1
描述:图1
Transplant kidney biopsy图2
名称:图2
描述:图2
Transplant kidney biopsy图3
名称:图3
描述:图3
Transplant kidney biopsy图4
名称:图4
描述:图4
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quhong 离线

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1 楼    发表于2009-05-09 12:30:00举报|引用
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 The final diagnosis is worded as following: acute tubular necrosis-like changes with positive C4d stain in peritubular capillaries, suggestive of acute antibody-mediated rejection, type I (Banff Classification 2005). There is focal interstitial mononuclear cell infiltration. It is focal, without tubulitis. It is not enough for the diagnosis of concurrent "borderline changes suspicious for acute T-cell-mediated rejeciton".

A definitive diagnosis of acute antibody mediated rejection requires: 1) morphologic evidence of acute tissue injury, 2) immunopathologic evidence for antibody action, and 3) serologic evidence of circulatingdonor-specific antibodies.  If only two of three criteria are present, such a case should be considered "suspicious for or suggestive of" acute antibody-mediated rejection.

In this case, the glomerulus is unremarkable. In the photo #2 and #3, there are lymphoid cells or moncytes in peritubular capillaries. This type of change is often seen in actue antibody-mediated rejection.
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