胶母

This is certainly a WHO grade IV malignant neoplasm. While most likely a glioblastoma, I would carefully rule out PNET by staining for GFAP and neuronal markers such as synaptophysin, NeuN and NSE. Rarely, PNET may shows marked pleomorphism and indistinguishable from glioblastoma on HE stain. 

 同意马老师的意见，该肿瘤从形态及年龄来看考虑PNET或GBM，须标记Syn、NSE、S-100、NeuN和GFAP来鉴别。

 结合图片细胞形态特点考虑胶质母细胞瘤，组化标记排除其他

 考虑胶质母细胞瘤

 谢谢各位老师，只是觉得不像PNET。

 中枢神经系统的PNET与GBM一样，也有不同的形态。需要鉴别

以下是引用xiaohl在2009-4-12 18:46:00的发言：  中枢神经系统的PNET与GBM一样，也有不同的形态。需要鉴别

请问老师PNET与GBM好像都属IV级吧，预后有差别吗？呵呵，我又该要去查查资料了。

PNET and GBM are both WHO grade IV, but they have distinct different biologic behavior. For instance, PNET is more likely to spread by CSF seeding at the beginning or at recurrence after resection. Response to various chemotherapeutic agents is also different between the two. Therefore it is important to distinguish them when you can.

 胶质母细胞瘤

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 胶质母

 PNET？胶母？

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