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| 名称： | |
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- 右甲状腺肿大
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| 姓 名： | ××× | 性别： | 女 | 年龄： | 47 |
| 标本名称： | 甲状腺。 | ||||
| 简要病史： | 右甲状腺肿大一月余。B超示多发囊实性结节，部分钙化。 | ||||
| 肉眼检查： | 多结节状，部分钙化，直径0.5cm。 | ||||
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本帖最后由 于 2009-02-10 12:23:00 编辑
×参考诊断
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zhongshihua 离线
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stevenshen 离线
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I also agree with most people that this is a papillary thyroid carcinoma on frozen.
I wonder why the immunostains were performed.
Can anyone who have had experience with CK19 and CD44v6 comment on this subject?
Is Ki67 helpful for a diagnosis of paillary thyroid carcinoma?
Thanks!
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stevenshen 离线
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- Thank you very much for the information. As you know, frozen section diagnosis of thyroid nodule is a frequent problem.
- One of the most common issues is papillary carcinoma or not.
- Follicular hyperplasia can have focal papillary growth and papillary carcinoma have a follicular variant, this is not only difficult by frozen section, but also difficult on permanent paraffin sections.
- So far there are no reliable markers that can reliably differentiate cases that are difficult to diagnose on paraffin sections, particularly follicular variant papillary thyroid carcinoma or follicular hyperplasia/adenoma/carcinoma.
- I certainly know about the use of CK19 and Galectin-3, have not heard about CD44v6 and Ki67.
- Agree with your final statment " 诊断一定要以H&E(+cytology)为基础，免疫组化仅做参考"
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shn-821128 离线
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