I think that this case demonstrates a coomon problem of some cases posted by our chinese pathologist. As some of you posted, the pictures are not clear, either because the slides quality is poor or the picture quality is poor, in any instance, I would not "kill myself" to try to classify this as either adenocarcinoma or squamous cell carcinoma. It is basically a non-small cell carcinoma. I always remind our residents and fellows, cytology is not 万能的。It has it's limitation. In this case, the quality of the pictures is the limitation. When there is limitation, I don't give a definitive diagnosis or subclassify the tumor. If the cliniian is ok with non-small cell carcinoma and patient's tumor is surgically removable, this diagnosis serves it's purpose. If it is not surgically removable and the clinician really needs subclassification to use different chemo-therapeutic agents to treat, then they need to get another good sample and good quality slides for me to subclassify.