本帖最后由 于 2007-07-31 17:57:00 编辑
The infiltrative and pseudoglandular pattern, associated necrosis, and cytologic features of the neoplasm are indeed most consistent with epithelioid angiosarcoma of thyroid gland. Anaplastic thyroid carcinoma and metastatic malignancy can be ruled out by appropriate immunohistochemistry - including CD31, factor VIII, thyroglobulin, and cytokeratins (AE1). The long history (40 years) suggest the lesion, if indeed an angiosarcoma, might have arisen from a pre-existing hemangioma. Can you share any immunohistochemical results and final diagnosis with us? This is a well illustrated and educational case!
以下是引用abin 在2006-11-4 14:09:00的发言:
学习mjma老师的讲解并试译如下:
浸润性和假腺样结构、合并坏死、细胞学特征确实非常符合甲状腺上皮样血管肉瘤。间变性甲状腺癌和转移性恶性肿瘤可能适当的免疫组化排除,包括:CD31、VIII因子、甲状腺球蛋白和CK(AE1)。长期病史(40年)提示本病,如果真是血管肉瘤,则可能发生于先前存在的血管瘤。能和我们分离免疫组化结果和最后诊断吗?这真是一例很好的图文并茂的教学病例!
The infiltrative and pseudoglandular pattern, associated necrosis, and cytologic features of the neoplasm are indeed most consistent with epithelioid angiosarcoma of thyroid gland. Anaplastic thyroid carcinoma and metastatic malignancy can be ruled out by appropriate immunohistochemistry - including CD31, factor VIII, thyroglobulin, and cytokeratins (AE1). The long history (40 years) suggest the lesion, if indeed an angiosarcoma, might have arisen from a pre-existing hemangioma. Can you share any immunohistochemical results and final diagnosis with us? This is a well illustrated and educational case!
以下是引用abin 在2006-11-4 14:09:00的发言:
学习mjma老师的讲解并试译如下:
浸润性和假腺样结构、合并坏死、细胞学特征确实非常符合甲状腺上皮样血管肉瘤。间变性甲状腺癌和转移性恶性肿瘤可能适当的免疫组化排除,包括:CD31、VIII因子、甲状腺球蛋白和CK(AE1)。长期病史(40年)提示本病,如果真是血管肉瘤,则可能发生于先前存在的血管瘤。能和我们分离免疫组化结果和最后诊断吗?这真是一例很好的图文并茂的教学病例!