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jianshu322 离线
stevenshen 离线
This has to be rare case - only heard about it, but do not have much experience.
- Frozen report: spindle cell neoplasm, defer to paraffin section for diagnosis
- Final diagnosis: to find evidence of epithelial differentiation is the key
1) is there any infiltrating ductal carcinoma or in situ carcinoma (history also)
2) suggestion of pan-cytokeratin stain is important
3) count mitoses, pleomorphism and necrosis
4) for specific diagnosis, either additional stain or consultation of soft tissue expert
5) to me, it is at least a low grade sarcomatoid neoplasm at this point;
6) treatment shoud be complete surgical resection with clear margin and follow up
以下是引用stevenshen在2008-11-16 22:10:00的发言:
This has to be rare case - only heard about it, but do not have much experience. - Frozen report: spindle cell neoplasm, defer to paraffin section for diagnosis - Final diagnosis: to find evidence of epithelial differentiation is the key 1) is there any infiltrating ductal carcinoma or in situ carcinoma (history also) 2) suggestion of pan-cytokeratin stain is important 3) count mitoses, pleomorphism and necrosis 4) for specific diagnosis, either additional stain or consultation of soft tissue expert 5) to me, it is at least a low grade sarcomatoid neoplasm at this point; 6) treatment shoud be complete surgical resection with clear margin and follow up |