Depend on types of tumors you want to differentiate.

1. Most common malignant epithelial carcinoma of oavry is high grade serous carcinoma.

Best margers: P53, WT1:more than 80 or 90% cases of the tumors are dissuely and strongly positive. P16 is strongly positive in most serous ca also.

2. Endometrioid ca: msot tumors are strongly and diffusely positive for ER. P53 and WT1 are negative in most cases or weakly focally positive in few cases.

3. Cear cell ca: No good markers in clinical use. P53, wt1 er can be positive or negative.

Some new markers, like hepatocyte nuclear factor (HNF0 1 beta and p-VHL can be spesific for ccc. I doubt they are clinically used in China.

Hope it can help.

 译cazhao的回复：

要看你要鉴别肿瘤的类型。

1。最常见的卵巢癌是高级别浆液性癌。较好的抗体有P53、WT1，80－90％以上的病例可见弥漫、很强的表达。P16在很多浆液性癌中也见很强的表达。

2。卵巢子宫内膜样癌：多是病例是会弥漫、强表达ER。P53和WT1在大多数病例中为阴性表达，少数病例中可见一些叫弱的或局灶性阳性表达。

3。透明细胞癌：没有什么太好的标记物，P53、WT1可以为阳性或阴性。

一些新的标记物，如：肝细胞核因子（HNF0 1 beta 和 p-VHL 在透明细胞癌中可能会更特异。但我不知道在中国它们是否已经被应用）

希望它对你有帮助。